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Karen S Anderson Selected Research

thymidylate synthase-dihydrofolate reductase

2/2014Virtual screening reveals allosteric inhibitors of the Toxoplasma gondii thymidylate synthase-dihydrofolate reductase.
10/2013First three-dimensional structure of Toxoplasma gondii thymidylate synthase-dihydrofolate reductase: insights for catalysis, interdomain interactions, and substrate channeling.
9/2013Exploring novel strategies for AIDS protozoal pathogens: α-helix mimetics targeting a key allosteric protein-protein interaction in C. hominis TS-DHFR.
9/2013Selective peptide inhibitors of bifunctional thymidylate synthase-dihydrofolate reductase from Toxoplasma gondii provide insights into domain-domain communication and allosteric regulation.
2/2008Probing the role of parasite-specific, distant structural regions on communication and catalysis in the bifunctional thymidylate synthase-dihydrofolate reductase from Plasmodium falciparum.

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Karen S Anderson Research Topics

Disease

57Neoplasms (Cancer)
07/2022 - 06/2003
24Breast Neoplasms (Breast Cancer)
07/2022 - 04/2008
15Infections
01/2022 - 05/2003
10Acquired Immunodeficiency Syndrome (AIDS)
10/2020 - 04/2002
7HIV Infections (HIV Infection)
01/2018 - 02/2004
6Ovarian Neoplasms (Ovarian Cancer)
12/2020 - 03/2009
6Oropharyngeal Neoplasms
02/2018 - 07/2015
5COVID-19
08/2021 - 08/2020
4Triple Negative Breast Neoplasms
11/2017 - 02/2011
4Malaria
09/2014 - 02/2008
3Drug-Related Side Effects and Adverse Reactions
01/2019 - 05/2010
3Lung Neoplasms (Lung Cancer)
01/2018 - 03/2007
3Carcinogenesis
12/2017 - 02/2004
3Mitochondrial Diseases (Mitochondrial Disease)
03/2013 - 05/2010
2Disease Progression
07/2022 - 06/2015
2Squamous Cell Carcinoma of Head and Neck
12/2020 - 11/2018
2Head and Neck Neoplasms (Head and Neck Cancer)
12/2020 - 01/2016
2Melanoma (Melanoma, Malignant)
05/2020 - 02/2015
2Uterine Cervical Neoplasms (Cancer of the Cervix)
12/2019 - 10/2018
2Carcinoma (Carcinomatosis)
06/2015 - 02/2004
2Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
04/2015 - 06/2012
2Human Influenza (Influenza)
06/2011 - 06/2003
2Breast Diseases (Breast Disease)
01/2011 - 01/2010
1Hot Flashes
05/2020
1Residual Neoplasm
01/2019
1Aneuploidy (Aneuploid)
11/2018
1Tetraploidy
11/2018
1Pancreatic Neoplasms (Pancreatic Cancer)
01/2018

Drug/Important Bio-Agent (IBA)

22Biomarkers (Surrogate Marker)IBA
01/2021 - 07/2005
19Proteins (Proteins, Gene)FDA Link
01/2022 - 07/2005
17AntigensIBA
12/2020 - 06/2003
13AntibodiesIBA
01/2021 - 07/2005
12AutoantibodiesIBA
12/2020 - 04/2008
11Pharmaceutical PreparationsIBA
01/2019 - 11/2003
10EnzymesIBA
10/2018 - 11/2003
9Neoplasm Antigens (Tumor Antigens)IBA
01/2017 - 07/2005
8VaccinesIBA
07/2022 - 07/2005
8Peptides (Polypeptides)IBA
01/2022 - 02/2004
8EpitopesIBA
03/2019 - 09/2010
8NucleosidesIBA
01/2019 - 06/2009
7Immunoglobulin G (IgG)IBA
01/2021 - 01/2011
7DNA (Deoxyribonucleic Acid)IBA
01/2021 - 08/2005
7Reverse Transcriptase InhibitorsIBA
01/2019 - 06/2009
6Estrogen ReceptorsIBA
05/2020 - 02/2011
5Antiviral Agents (Antivirals)IBA
03/2021 - 07/2014
5Phosphotransferases (Kinase)IBA
05/2015 - 03/2007
5thymidylate synthase-dihydrofolate reductaseIBA
02/2014 - 02/2008
4Biological ProductsIBA
10/2018 - 01/2010
4NucleotidesIBA
12/2014 - 02/2008
3Peptide Hydrolases (Proteases)FDA Link
03/2021 - 08/2020
3Complement System Proteins (Complement)IBA
01/2021 - 01/2020
3DNA Polymerase gammaIBA
01/2019 - 05/2010
3N 30IBA
01/2018 - 03/2010
3AutoantigensIBA
01/2017 - 02/2004
3Gefitinib (Iressa)FDA Link
04/2015 - 03/2007
3Thymidylate SynthaseIBA
09/2014 - 10/2013
3Folic Acid (Vitamin M)FDA LinkGeneric
09/2014 - 01/2009
3HLA-A*02:01 antigenIBA
06/2011 - 06/2003
2Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA
07/2022 - 08/2005
2Tumor Biomarkers (Tumor Markers)IBA
01/2021 - 12/2017
2Immune Checkpoint InhibitorsIBA
03/2019 - 01/2016
2Cancer VaccinesIBA
12/2018 - 05/2009
2OligonucleotidesIBA
11/2018 - 09/2015
2CytosineIBA
10/2018 - 07/2002
2InterferonsIBA
10/2018 - 03/2009
2Oncogene Proteins (Oncogene Protein)IBA
12/2017 - 09/2010
2Human immunodeficiency virus 1 reverse transcriptaseIBA
01/2017 - 08/2010
2Mitochondrial DNA (mtDNA)IBA
01/2016 - 06/2010
2Erlotinib Hydrochloride (CP 358,774)FDA Link
04/2015 - 03/2007
2Tenofovir (Viread)FDA Link
12/2014 - 08/2012
2Tetrahydrofolate Dehydrogenase (Dihydrofolate Reductase)IBA
09/2014 - 10/2013
2LigandsIBA
08/2014 - 02/2011
2Immunodominant EpitopesIBA
08/2014 - 06/2003
2RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA
07/2014 - 12/2007
2Antiparasitic Agents (Antiparasitics)IBA
10/2013 - 09/2013
2Viral AntigensIBA
06/2011 - 06/2003
2IntegrinsIBA
04/2011 - 02/2011
1Drug CombinationsIBA
01/2022
1perampanelIBA
03/2021
1Azacitidine (5 Azacytidine)FDA Link
12/2020
1MethyltransferasesIBA
05/2020
1Acetates (Acetic Acid Esters)FDA Link
05/2020
1Estrogens (Estrogen)FDA Link
05/2020
1Papillomavirus Vaccines (HPV Vaccines)IBA
12/2019
1AZD4547IBA
01/2019
1Circulating Tumor DNAIBA
01/2019
14- chloro- 3',6'- dimethyl- 2,2'- iminodibenzoate (TO 115)IBA
01/2019
1Small Interfering RNA (siRNA)IBA
01/2019
1Tumor Viral Antigens (Large T Antigen)IBA
11/2018
1Indoleamine-Pyrrole 2,3,-Dioxygenase (Indoleamine 2,3 Dioxygenase)IBA
11/2018
1UracilIBA
10/2018
1CytidineIBA
10/2018
1ApolipoproteinsIBA
10/2018
1ImmunosorbentsIBA
02/2018
1Polysaccharides (Glycans)IBA
01/2018

Therapy/Procedure

19Therapeutics
08/2021 - 11/2003
8Immunotherapy
03/2019 - 06/2003
3Highly Active Antiretroviral Therapy (HAART)
10/2020 - 07/2008
3Drug Therapy (Chemotherapy)
12/2017 - 08/2005
2Neoadjuvant Therapy
01/2019 - 12/2017